Health

When should we expect to have the COVID-19 vaccine?

The COVID 19 virus has the world in turmoil. It has managed to significantly diminish the human and economic resources of countries. Each day witnesses a new rise in cases and number of deaths. While everybody is eagerly waiting for life to go back to normal, the end of this pandemic looks quite uncertain. Just out of curiosity, how do you think this will end? Everyone wants to know about the latest update of the COVID-19 vaccine.

One solution can be achieving herd immunity. Herd immunity can be reached if 70-90% of the population is exposed to the virus and recovers from the disease to develop antibodies against future infection. This would break the chain of transmission and provide indirect protection to those who are not immune to the virus. However, with a fatality rate of 0.5-1%, achieving herd immunity would entail a high human cost. Also, the immunity gained after recovering from the virus is not permanent, meaning that in a few months after recovery, you’ll again be at a risk of getting infected. This makes herd immunity an impractical and far fetched approach. This is why, as acknowledged by WHO, CDC and MoHFW, a vaccine is the only answer to triumph over COVID-19.

In layman’s terms, a vaccine or immunization is a medicine that prevents a particular disease. It is important to know that it is not a curative but a preventive measure. The concept behind a vaccine is to stimulate an antibody memory response without producing an illness. Thus, it mimics the virus it protects against, causing a fight-back response from the immune system. This way, when the actual virus enters the body, the antibodies are ready to tackle it. But is there a vaccine for every disease? There’s no guarantee. For example, a vaccine against the Ebola virus was developed in five years whereas the vaccine against AIDS still does not exist. However, due to the urgency of the situation, the vaccine against COVID19 is being developed at a much faster rate than any other vaccine. The entire world has invested all of its time and resources into developing a safe and effective vaccine for this pandemic.

Development of a vaccine is a long and stringent process. The vaccine passes through a number of layered trials before getting approved for general use. Since the risks associated with an unsafe vaccine are high, it is dangerous to haste the development procedure by compromising on the efficacy of the product. Such strict measures are imperative to ensure no side effects in a vaccine, since side effects of an unsafe vaccine can potentially be more dangerous than the disease it is supposed to protect against. Currently, more than 170 teams of researchers are racing to develop a safe and effective vaccine. Despite the cumulative efforts, a cloud of uncertainty floats over the future of COVID 19 vaccine. The below table will give you a brief understanding of the various stages of vaccine development and also a quick update on the number of candidates at each stage:

COVID-19 vaccine
COVID-19 vaccine

Once a COVID-19 vaccine clears the benchmarking process and receives approval from the respective authorities, it is ready for large scale production and subsequent distribution. Manufacturers with large scale production capacity get the license to produce the vaccines in bulk. This license includes stringent measures on quality control. Once the vaccine is produced, it is distributed as per dissemination protocol set by the government, generally in the following order of priority:

  • Frontline workers – medical staff, public administration officials etc.
  • Vulnerable sections – children, senior citizens, persons with comorbidities
  • General public

A vaccine may also get “emergency use authorization” before getting final approval when the exigencies of the pandemic situation calls for it. Two such vaccines, China’s Sinovac and Russia’s Sputnik V, have been launched without clearing the Phase 3 stage in the vaccine development process. This has raised some serious concerns about their safety. A recent study has reported that 1 in every 7 individuals who have been administered the Sputnik V vaccine have reported mild side-effects like body pain, sore throat and headache. However, Russia has planned a global Phase 3 study of its vaccine, involving 45000 volunteers. Russia has proposed  to include India as a part of this global bridge trial and the country has also signed a pact with Dr Reddy’s Laboratory, a leading multinational pharmaceutical company based in India, for distribution of the vaccine upon successful completion of Phase 3 trials and registration with Indian regulators.

The Serum Institute of India, based in Pune, is the world’s largest COVID-19 vaccine producer. It is in a collaborative tie with the University of Oxford to conduct the Phase 3 human trials of the ‘Covishield’ vaccine, the candidate of the AstraZeneca-Oxford University. It is expected to be the first vaccine to be released in India and will be produced in large quantities by the Serum Institute. Although the global trials of the aforementioned vaccine were temporarily halted due to a case of spinal inflammation in one of the volunteers, it has received the green flag to continue testing after the required investigation. The Serum Institute has declared that the price of this vaccine will be capped at Rs 225 per dose and will be released in Q1 2021. This was also confirmed by Dr Harsh Vardhan, the Union Health Minister of India. According to Adar Poonawala, CEO of the Serum Institute of India, the task of buying and distribution of vaccines to immunize the entire nation will be Rs. 80,000 crores assuming 2 doses per person. This poses a concerning challenge to the MoHFW and PMO, if the government were to bear the cost of this immunization programme.

While leading COVID-19 vaccine candidates are advancing at an exceptional rate to advanced stages of clinical development, many uncertainties remain, given the complexity of the COVID-19 vaccine development process and the limited data available to date. Despite this, the hope persists that a viable, safe, and efficient vaccine will be developed soon. Until then, it is our responsibility to maintain social distancing and appropriate hygiene. Step out of your home only if absolutely necessary and wear a mask when you do. Let’s pledge to fight this invisible enemy responsibly.

COVID-19 vaccine

Stay Healthy ! Stay Protected !

A version of this post first appeared on HealthySure. We welcome your comments at <media house id>.

Related posts
Health

6 Chest And Triceps Exercises For Muscle Building

Training your chest and triceps muscle together is the best way to build muscles. Preparing them…
Read more
Health

13 Important Activities to Indulge in After Heart Stroke Treatment

Recovering from a heart stroke is all about making intelligent lifestyle changes. While a treatment…
Read more
Health

Getting an Abortion? Know About the Risks, Dangers, and Complications?

Abortions are fairly common and roughly a million take place every year in the United States. Given…
Read more
Newsletter
Become a Trendsetter

Sign up for Miska’s Daily Digest and get the best of miska, tailored for you.

Leave a Reply

Your email address will not be published. Required fields are marked *